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Morphine

Opioidoral · inferred

Reference opioid agonist and primary active metabolite of heroin and codeine. Undergoes hepatic glucuronidation to active M6G (more potent, longer-acting) and inactive M3G. Terminal half-life ~2-3 hours for immediate release.

Projected serum levels — 10 mg, as needed (shown daily)

Morphine
Morphine modeled serum levels, 10 mg as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.50 1 1.5 2 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 10 mg as needed (shown daily) (oral).

Modeled steady state after ~1 days: peak ≈ 1.9 mg, trough ≈ 0.004 mg body load. Population-based estimate over 15 days for a 10 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Opioid
Route modeled
Oral
Model confidence
inferred
Half-life
2.5 h
Common dose
10 mg
Reference dose range
2–90 mg (single dose)
Suggested cadence
as needed (shown daily)
Validated against
30 mg oral — Cmax 0.050 mg/L at 1 h

Documented interactions

  • danger
    1,4-BDO (1,4-Butanediol) + Morphine Contraindicated

    1,4-BDO converts to GHB. Stacked with opioid respiratory depression, often fatal.

  • danger
    7-Hydroxymitragynine (7-OH) + Morphine Stacked effects

    7-Hydroxymitragynine (7-OH) and Morphine both push the delta opioid, kappa opioid, and mu opioid in the same direction.

  • danger
    CBD (Cannabidiol) + Morphine CYP inhibition

    CBD (Cannabidiol) reversible_inhibitor of UGT2B7 predicted to change Morphine AUC by ~2.47x

  • danger
    Cocaine + Morphine Contraindicated

    Speedball combination: stimulant masks opioid sedation, leading to accidental overdose. Extreme cardiac strain.

  • danger
    Codeine + Morphine Contraindicated

    Combining opioids causes additive respiratory depression. Codeine is metabolized to morphine.

  • danger
    Ethanol (Alcohol) + Morphine Contraindicated

    Alcohol potentiates opioid respiratory depression.

Serum checks 52 modeled interaction pairings for morphine across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Clinical Pharmacokinetics of Morphine Sawe J · Clinical Pharmacokinetics, 1986 DOI

    Comprehensive review of morphine pharmacokinetics including oral bioavailability of 20-30%, hepatic first-pass metabolism, glucuronidation to M3G and active M6G, and a terminal half-life of 2-3 hours.

  2. Morphine in Postoperative Patients: Pharmacokinetics and Pharmacodynamics of Metabolites Lotsch J et al. · Anesthesia & Analgesia, 2006 DOI

    Found morphine-6-glucuronide was 7.8 times more potent than morphine but with a delayed peak effect of 4.25 h compared to 0.33 h for morphine in postoperative patients.

  3. A Review of Morphine and Morphine-6-Glucuronide Pharmacokinetic-Pharmacodynamic Relationships in Experimental and Clinical Pain Klimas R, Mikus G · European Journal of Pharmaceutical Sciences, 2014 DOI

    Reviewed population PK-PD models for morphine analgesia, covering drug disposition, active M6G metabolite pharmacology, and clinical variability in pain response.

  4. Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial Krebs EE et al. · JAMA, 2018 DOI

    12-month RCT of 240 veterans found opioids (including sustained-release morphine) were NOT superior to non-opioid therapy for pain-related function in chronic back/hip/knee pain; pain intensity was actually worse in the…

5 published studies referenced in the app, each with a plain-language summary.