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Lithium Orotate (Microdose)

Mineraloral · inferred

Lithium at nutritional/microdose levels (5-20 mg elemental). Unlike prescription lithium carbonate (300-1200 mg), orotate form is used at ~1/100th the dose. Epidemiological studies link trace lithium in drinking water to lower suicide rates, dementia incidence, and all-cause mortality.

Projected serum levels — 5 mg, once daily

Lithium Orotate (Microdose)
Lithium Orotate (Microdose) modeled serum levels, 5 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 1.3 2.5 3.8 5 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 5 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 3.1 mg, trough ≈ 0.030 mg body load. Population-based estimate over 15 days for a 5 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Mineral
Route modeled
Oral
Model confidence
inferred
Half-life
3.1 h
Common dose
5 mg
Suggested maximum
20 mg/day
Reference dose range
2.5–20 mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    1P-LSD (1-Propionyl-LSD) + Lithium Orotate (Microdose) Contraindicated

    Lithium combined with psychedelics significantly increases seizure risk. 1P-LSD is a prodrug to LSD.

  • danger
    25I-NBOMe + Lithium Orotate (Microdose) Contraindicated

    Lithium combined with psychedelics significantly increases seizure risk. 25I-NBOMe is already highly dangerous on its own — adding lithium dramatically increases seizure and fatality risk.

  • danger
    2C-B (4-Bromo-2,5-dimethoxyphenethylamine) + Lithium Orotate (Microdose) Contraindicated

    Lithium combined with psychedelics significantly increases seizure risk. 2C-B is a serotonergic psychedelic.

  • danger
    4-AcO-DMT (Psilacetin) + Lithium Orotate (Microdose) Contraindicated

    Lithium combined with psychedelics significantly increases seizure risk. 4-AcO-DMT is a prodrug to psilocin (same pharmacology as psilocybin).

  • danger
    Ayahuasca (DMT + Harmaline) + Lithium Orotate (Microdose) Contraindicated

    Lithium combined with psychedelics significantly increases seizure risk. Ayahuasca contains DMT (5-HT2A agonist) plus MAO inhibitors that further complicate the interaction.

  • danger
    DMT (N,N-Dimethyltryptamine) + Lithium Orotate (Microdose) Contraindicated

    Lithium combined with psychedelics significantly increases seizure risk. DMT is a potent 5-HT2A agonist.

Serum checks 19 modeled interaction pairings for lithium orotate (microdose) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Association Between Lithium in Drinking Water and Incidence of Dementia Kessing LV et al. · JAMA Psychiatry, 2017 DOI

    Danish nationwide study of 73,731 dementia patients showing higher lithium levels in drinking water were associated with lower incidence of dementia.

  2. Lithium in Drinking Water and Suicide Mortality Ohgami H et al. · British Journal of Psychiatry, 2009 DOI

    Found significant inverse correlation between lithium levels in tap water and suicide rates across 18 Japanese municipalities.

  3. Lithium in the Prevention of Alzheimer Disease and Related Dementias: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Matsunaga S et al. · Journal of Alzheimer Disease, 2015 DOI

    Meta-analysis of RCTs showing lithium reduces cognitive decline in Alzheimer patients, supporting neuroprotective effects at therapeutic and trace doses.

  4. Lithium orotate in the treatment of alcoholism and related conditions. Sartori HE · Alcohol (Fayetteville, N.Y.), 1986 DOI

    This citation reports a human primary study involving Lithium Orotate (Microdose). It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

4 published studies referenced in the app, each with a plain-language summary.