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Ibuprofen (Advil / Motrin)

Analgesicoral · predicted

Non-steroidal anti-inflammatory drug (NSAID) used for pain, fever, and inflammation. Short half-life requires dosing every 4-6 hours.

Projected serum levels — 400 mg, as needed (shown daily)

Ibuprofen (Advil / Motrin)
Ibuprofen (Advil / Motrin) modeled serum levels, 400 mg as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 125 250 375 500 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 400 mg as needed (shown daily) (oral).

Modeled steady state after ~1 days: peak ≈ 324 mg, trough ≈ 23.5 mg body load. Population-based estimate over 15 days for a 400 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Analgesic
Route modeled
Oral
Model confidence
predicted
Half-life
2 h
Common dose
400 mg
Suggested maximum
3.2k mg/day
Reference dose range
100–3.2k mg (single dose)
Suggested cadence
as needed (shown daily)
Validated against
400 mg oral — Cmax 25 mg/L at 1.5 h

Documented interactions

  • danger
    Levothyroxine (Synthroid) + Ibuprofen (Advil / Motrin) Protein binding

    Ibuprofen (Advil / Motrin) may displace Levothyroxine (Synthroid) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free…

  • danger
    Rifampin + Ibuprofen (Advil / Motrin) CYP induction

    Rifampin inducer of CYP2C9 predicted to change Ibuprofen (Advil / Motrin) AUC by ~0.45x

  • danger
    Tacrolimus (Prograf) + Ibuprofen (Advil / Motrin) Protein binding

    Ibuprofen (Advil / Motrin) may displace Tacrolimus (Prograf) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free…

  • danger
    Warfarin (Coumadin) + Ibuprofen (Advil / Motrin) Protein binding

    Ibuprofen (Advil / Motrin) may displace Warfarin (Coumadin) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free…

  • warning
    Apigenin + Ibuprofen (Advil / Motrin) Protein binding

    Apigenin may displace Ibuprofen (Advil / Motrin) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Aripiprazole (Abilify) + Ibuprofen (Advil / Motrin) Protein binding

    Aripiprazole (Abilify) may displace Ibuprofen (Advil / Motrin) from plasma protein binding sites, transiently raising free drug concentration.

Serum checks 163 modeled interaction pairings for ibuprofen (advil / motrin) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Single dose oral ibuprofen for acute postoperative pain in adults Derry C et al. · Cochrane Database of Systematic Reviews, 2009 DOI

    Cochrane review found ibuprofen 400 mg provided effective analgesia in over 70% of patients with moderate to severe postoperative pain, with NNT of 2.5.

  2. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials Coxib and traditional NSAID Trialists Collaboration · Lancet, 2013 DOI

    Major meta-analysis of 280,000+ participants found high-dose ibuprofen increased coronary events similarly to COX-2 inhibitors, while naproxen did not increase vascular risk.

  3. Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review Pierce CA et al. · Annals of Pharmacotherapy, 2010 DOI

    Meta-analysis found ibuprofen provided superior pain relief and fever reduction compared to acetaminophen in both children and adults, with comparable safety profiles.

3 published studies referenced in the app, each with a plain-language summary.