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Gabapentin (Neurontin)

Anticonvulsantprescriptionoral · inferred

GABA analogue that does not bind GABA receptors but modulates calcium channels. Used for neuropathic pain, seizures, and anxiety. Not hepatically metabolized.

Projected serum levels — 300 mg, twice daily

Gabapentin (Neurontin)
Gabapentin (Neurontin) modeled serum levels, 300 mg twice daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 50 100 150 200 Day 0 Day 4 Day 7 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 300 mg twice daily (oral).

Modeled steady state after ~1 days: peak ≈ 109 mg, trough ≈ 24.0 mg body load. Population-based estimate over 15 days for a 300 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Anticonvulsant
Route modeled
Oral
Model confidence
inferred
Half-life
6 h
Common dose
300 mg
Suggested maximum
3.6k mg/day
Reference dose range
100–3.6k mg (single dose)
Suggested cadence
twice daily
Validated against
300 mg oral — Cmax 2.7 mg/L at 3 h

Documented interactions

  • danger
    7-Hydroxymitragynine (7-OH) + Gabapentin (Neurontin) Contraindicated

    FDA black box warning equivalent: gabapentinoids combined with opioids dramatically increase risk of respiratory depression and death. 7-Hydroxymitragynine is a potent mu-opioid agonist — this…

  • danger
    Codeine + Gabapentin (Neurontin) Potentiation

    Gabapentin + opioids significantly increases respiratory depression risk. FDA black box warning.

  • danger
    Heroin / 6-MAM + Gabapentin (Neurontin) Potentiation

    Gabapentin + opioids causes severe respiratory depression. Heroin already carries extreme overdose risk.

  • danger
    Hydrocodone + Gabapentin (Neurontin) Potentiation

    Gabapentin + opioids significantly increases respiratory depression risk.

  • danger
    Morphine + Gabapentin (Neurontin) Potentiation

    Gabapentin + opioids significantly increases respiratory depression risk.

  • danger
    Oxycodone + Gabapentin (Neurontin) Potentiation

    Gabapentin + opioids significantly increases respiratory depression risk. FDA black box warning.

Serum checks 12 modeled interaction pairings for gabapentin (neurontin) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial Rowbotham M et al. · JAMA, 1998 DOI

    Pivotal RCT of 229 patients found gabapentin (up to 3600 mg/day) significantly reduced postherpetic neuralgia pain by 33% compared to 8% for placebo, establishing its role in neuropathic pain.

  2. A randomized, double-blind, placebo-controlled trial of gabapentin for the treatment of generalized anxiety disorder Pande AC et al. · Journal of Clinical Psychiatry, 2000 DOI

    RCT found gabapentin 600-3600 mg/day significantly reduced anxiety symptoms compared to placebo in patients with generalized anxiety disorder.

  3. Pharmacological management of neuropathic pain: evidence-based recommendations Finnerup NB et al. · Lancet Neurology, 2015 DOI

    Systematic review and meta-analysis recommending gabapentin as a first-line treatment for neuropathic pain, with NNT of 6.3 for 50% pain relief.

3 published studies referenced in the app, each with a plain-language summary.