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GABA (Gamma-Aminobutyric Acid)

Amino Acidoral · inferred

Primary inhibitory neurotransmitter. Oral GABA has limited blood-brain barrier penetration, but may act via the enteric nervous system and promote relaxation.

Projected serum levels — 500 mg, once daily

GABA (Gamma-Aminobutyric Acid)
GABA (Gamma-Aminobutyric Acid) modeled serum levels, 500 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 6.3 12.5 18.8 25 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 500 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 20.8 mg, trough ≈ 0.56 mg body load. Population-based estimate over 15 days for a 500 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Amino Acid
Route modeled
Oral
Model confidence
inferred
Half-life
2.8 h
Common dose
500 mg
Suggested maximum
1.5k mg/day
Reference dose range
250–1.5k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    GHB (Gamma-Hydroxybutyrate) + GABA (Gamma-Aminobutyric Acid) Potentiation

    GHB acts on GABA-B receptors. Additional GABA supplementation increases CNS depression risk.

  • warning
    Ethanol (Alcohol) + GABA (Gamma-Aminobutyric Acid) Potentiation

    GABA supplementation may enhance the sedative effects of alcohol, increasing CNS depression.

  • caution
    1,4-BDO (1,4-Butanediol) + GABA (Gamma-Aminobutyric Acid) Potentiation

    1,4-BDO converts to GHB (GABA-B agonist). Oral GABA itself crosses the blood-brain barrier poorly, but the perceived sedation can mask early signs of GHB overdose.

  • moderate
    Phenibut (beta-Phenyl-GABA) + GABA (Gamma-Aminobutyric Acid) Stacked effects

    GABA (Gamma-Aminobutyric Acid) and Phenibut (beta-Phenyl-GABA) both push the gaba a and gaba b in the same direction.

  • watch
    Apigenin + GABA (Gamma-Aminobutyric Acid) Stacked effects

    Apigenin and GABA (Gamma-Aminobutyric Acid) both push the gaba a in the same direction.

  • watch
    Ashwagandha (KSM-66) + GABA (Gamma-Aminobutyric Acid) Stacked effects

    Ashwagandha (KSM-66) and GABA (Gamma-Aminobutyric Acid) both push the gaba a in the same direction.

Serum checks 36 modeled interaction pairings for gaba (gamma-aminobutyric acid) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans Abdou AM et al. · BioFactors, 2006 DOI

    Study found oral GABA (100 mg) significantly increased alpha brain waves and decreased beta waves within one hour, indicating relaxation without drowsiness.

  2. Oral intake of gamma-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks Yoto A et al. · Amino Acids, 2012 DOI

    Study found oral GABA (28 mg) reduced stress markers and improved parasympathetic nervous system tone during mentally stressful arithmetic tasks.

2 published studies referenced in the app, each with a plain-language summary.