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Fermented foods (tyramine)

Foodoral · inferred

Aged cheese, cured meat, soy sauce, fermented cabbage, red wine deliver dietary tyramine. Normally MAO-A-degraded in gut; in MAOI users tyramine reaches circulation causing hypertensive crisis (the "cheese effect"). Confidence: high for historical MAOI class.

Projected serum levels — 1 serving (≈ 1 mg), as needed (shown daily)

Fermented foods (tyramine)
Fermented foods (tyramine) modeled serum levels, 1 serving (≈ 1 mg) as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 7 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 7

Maintenance schedule: 1 serving (≈ 1 mg) as needed (shown daily) (oral).

Modeled steady state after ~7 days: peak ≈ 0 mg, trough ≈ 0 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Food
Route modeled
Oral
Model confidence
inferred
Common dose
1 serving (≈ 1 mg)
Suggested maximum
3 serving/day
Reference dose range
1–3 serving (single dose)
Suggested cadence
as needed (shown daily)

Documented interactions

  • danger
    Peyote (Mescaline Cactus) + Fermented foods (tyramine) CYP inhibition

    Fermented foods (tyramine) reversible_inhibitor of MAO_A predicted to change Peyote (Mescaline Cactus) AUC by ~2.50x

  • danger
    Sumatriptan (Imitrex) + Fermented foods (tyramine) CYP inhibition

    Fermented foods (tyramine) reversible_inhibitor of MAO_A predicted to change Sumatriptan (Imitrex) AUC by ~3.33x

  • moderate
    d-Amphetamine + Fermented foods (tyramine) Stacked effects

    d-Amphetamine and Fermented foods (tyramine) both push the NET and TAAR1 in the same direction.

  • moderate
    Lisdexamfetamine (Vyvanse) + Fermented foods (tyramine) Stacked effects

    Fermented foods (tyramine) and Lisdexamfetamine (Vyvanse) both push the NET and TAAR1 in the same direction.

  • moderate
    Methylphenidate (Ritalin) + Fermented foods (tyramine) Stacked effects

    Fermented foods (tyramine) and Methylphenidate (Ritalin) both push the NET and TAAR1 in the same direction.

  • watch
    Amphetamine (Adderall) + Fermented foods (tyramine) Stacked effects

    Amphetamine (Adderall) and Fermented foods (tyramine) both push the TAAR1 in the same direction.

Serum checks 33 modeled interaction pairings for fermented foods (tyramine) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.