Home › Compound Library › Baclofen (Lioresal)

Baclofen (Lioresal)

Muscle Relaxantprescriptionoral · inferred

GABA-B receptor agonist used for spasticity from spinal cord injury, MS, and cerebral palsy. Also used off-label for alcohol use disorder (reduces craving and withdrawal). Crosses blood-brain barrier poorly (hence high doses needed orally), intrathecal pump available for refractory spasticity. ~80% oral bioavailability, predominantly renally eliminated unchanged. Abrupt discontinuation risk: withdrawal can cause seizures, hallucinations, and autonomic instability.

Projected serum levels — 10 mg, once daily

Baclofen (Lioresal)
Baclofen (Lioresal) modeled serum levels, 10 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 1.3 2.5 3.8 5 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 10 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 4.8 mg, trough ≈ 0.009 mg body load. Population-based estimate over 15 days for a 10 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Muscle Relaxant
Route modeled
Oral
Model confidence
inferred
Half-life
3.8 h
Common dose
10 mg
Suggested maximum
80 mg/day
Reference dose range
5–80 mg (single dose)
Suggested cadence
once daily
Validated against
10 mg oral — Cmax 0.18 mg/L at 1 h

Documented interactions

  • watch
    1,4-BDO (1,4-Butanediol) + Baclofen (Lioresal) Stacked effects

    1,4-BDO (1,4-Butanediol) and Baclofen (Lioresal) both push the gaba b in the same direction.

  • watch
    GABA (Gamma-Aminobutyric Acid) + Baclofen (Lioresal) Stacked effects

    Baclofen (Lioresal) and GABA (Gamma-Aminobutyric Acid) both push the gaba b in the same direction.

  • watch
    GBL (Gamma-Butyrolactone) + Baclofen (Lioresal) Stacked effects

    Baclofen (Lioresal) and GBL (Gamma-Butyrolactone) both push the gaba b in the same direction.

  • watch
    GHB (Gamma-Hydroxybutyrate) + Baclofen (Lioresal) Stacked effects

    Baclofen (Lioresal) and GHB (Gamma-Hydroxybutyrate) both push the gaba b in the same direction.

  • watch
    Phenibut (beta-Phenyl-GABA) + Baclofen (Lioresal) Stacked effects

    Baclofen (Lioresal) and Phenibut (beta-Phenyl-GABA) both push the gaba b in the same direction.

Serum checks 5 modeled interaction pairings for baclofen (lioresal) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Baclofen for the treatment of alcohol dependence: a randomized, double-blind, placebo-controlled trial Addolorato G et al. · Lancet, 2007 DOI

    RCT (84 alcohol-dependent patients) demonstrating baclofen 30 mg/day significantly increased abstinence rate (71% vs 29% placebo) and reduced craving, introducing a novel pharmacotherapy for alcohol dependence.

  2. Clinical pharmacokinetics of baclofen Wuis EW et al. · Clinical Pharmacokinetics, 1989 DOI

    PK review establishing baclofen half-life of 3-5 hours, 80% oral bioavailability, predominantly unchanged renal elimination (70-80%), and linear pharmacokinetics up to 80 mg/day.

2 published studies referenced in the app, each with a plain-language summary.