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Tongkat Ali (Eurycoma longifolia)

Herboral · inferred

Southeast Asian herb with low oral bioavailability (~10.5%). Used to support testosterone levels, libido, and stress management. Key active compound is eurycomanone.

Projected serum levels — 400 mg, once daily

Tongkat Ali (Eurycoma longifolia)
Tongkat Ali (Eurycoma longifolia) modeled serum levels, 400 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 6.3 12.5 18.8 25 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 400 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 20.2 mg, trough ≈ 0.19 mg body load. Population-based estimate over 15 days for a 400 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Herb
Route modeled
Oral
Model confidence
inferred
Half-life
2.8 h
Common dose
400 mg
Suggested maximum
1.2k mg/day
Reference dose range
200–1.2k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • contraindicated
    Carbamazepine (Tegretol) + Tongkat Ali (Eurycoma longifolia) CYP induction

    Carbamazepine (Tegretol) inducer of CYP3A4 predicted to change Tongkat Ali (Eurycoma longifolia) AUC by ~0.20x

  • contraindicated
    Clarithromycin (Biaxin) + Tongkat Ali (Eurycoma longifolia) CYP inhibition

    Clarithromycin (Biaxin) mechanism_based of CYP3A4 predicted to change Tongkat Ali (Eurycoma longifolia) AUC by ~10.00x

  • contraindicated
    Dasatinib (Sprycel) + Tongkat Ali (Eurycoma longifolia) CYP inhibition

    Dasatinib (Sprycel) time_dependent_inhibitor of CYP3A4 predicted to change Tongkat Ali (Eurycoma longifolia) AUC by ~5.00x

  • contraindicated
    Diltiazem + Tongkat Ali (Eurycoma longifolia) CYP inhibition

    Diltiazem mechanism_based of CYP3A4 predicted to change Tongkat Ali (Eurycoma longifolia) AUC by ~10.00x

  • contraindicated
    Efavirenz (Sustiva) + Tongkat Ali (Eurycoma longifolia) CYP induction

    Efavirenz (Sustiva) inducer of CYP3A4 predicted to change Tongkat Ali (Eurycoma longifolia) AUC by ~0.12x

  • contraindicated
    Grapefruit (whole fruit) + Tongkat Ali (Eurycoma longifolia) CYP inhibition

    Grapefruit (whole fruit) mechanism_based of CYP3A4 predicted to change Tongkat Ali (Eurycoma longifolia) AUC by ~10.00x

Serum checks 62 modeled interaction pairings for tongkat ali (eurycoma longifolia) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects Talbott SM et al. · Journal of the International Society of Sports Nutrition, 2013 DOI

    RCT found 200 mg/day Tongkat Ali for 4 weeks significantly reduced cortisol by 16%, increased testosterone by 37%, and improved mood and stress profiles.

  2. Eurycoma longifolia Jack in managing idiopathic male infertility Ismail SB et al. · Asian Journal of Andrology, 2012 DOI

    Study found 200 mg/day of Tongkat Ali for 9 months significantly improved sperm concentration, motility, and quality in infertile men, with 14.7% achieving spontaneous pregnancies.

  3. Review on a traditional herbal medicine, Eurycoma longifolia Jack (Tongkat Ali): its traditional uses, chemistry, evidence-based pharmacology and toxicology Rehman SU et al. · Molecules, 2016 DOI

    Comprehensive review of Tongkat Ali pharmacology covering its anti-estrogenic, pro-testosterone, adaptogenic, and antimalarial properties with toxicological safety data.

3 published studies referenced in the app, each with a plain-language summary.