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Grapefruit (whole fruit)

Foodoral · inferred

Whole fresh grapefruit contains furanocoumarins (bergamottin, 6',7'-dihydroxybergamottin) that irreversibly inactivate intestinal CYP3A4 via mechanism-based inhibition. One grapefruit produces ~50% enterocyte CYP3A4 loss; effect lasts 24-72 h. Confidence: high.

Projected serum levels — 1 fruit (≈ 1 mg), as needed (shown daily)

Grapefruit (whole fruit)
Grapefruit (whole fruit) modeled serum levels, 1 fruit (≈ 1 mg) as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 7 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 7

Maintenance schedule: 1 fruit (≈ 1 mg) as needed (shown daily) (oral).

Modeled steady state after ~7 days: peak ≈ 0 mg, trough ≈ 0 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Food
Route modeled
Oral
Model confidence
inferred
Common dose
1 fruit (≈ 1 mg)
Suggested maximum
2 fruit/day
Reference dose range
0.50–2 fruit (single dose)
Suggested cadence
as needed (shown daily)

Documented interactions

  • contraindicated
    Alfuzosin (Uroxatral) + Grapefruit (whole fruit) CYP inhibition

    Grapefruit (whole fruit) mechanism_based of CYP3A4 predicted to change Alfuzosin (Uroxatral) AUC by ~10.00x

  • contraindicated
    Alprazolam (Xanax) + Grapefruit (whole fruit) CYP inhibition

    Grapefruit (whole fruit) mechanism_based of CYP3A4 predicted to change Alprazolam (Xanax) AUC by ~10.00x

  • contraindicated
    Amlodipine (Norvasc) + Grapefruit (whole fruit) CYP inhibition

    Grapefruit (whole fruit) mechanism_based of CYP3A4 predicted to change Amlodipine (Norvasc) AUC by ~10.00x

  • contraindicated
    Anastrozole (Arimidex) + Grapefruit (whole fruit) CYP inhibition

    Grapefruit (whole fruit) mechanism_based of CYP3A4 predicted to change Anastrozole (Arimidex) AUC by ~5.14x

  • contraindicated
    Astaxanthin + Grapefruit (whole fruit) CYP inhibition

    Grapefruit (whole fruit) mechanism_based of CYP3A4 predicted to change Astaxanthin AUC by ~10.00x

  • contraindicated
    Atogepant (Qulipta) + Grapefruit (whole fruit) CYP inhibition

    Grapefruit (whole fruit) mechanism_based of CYP3A4 predicted to change Atogepant (Qulipta) AUC by ~10.00x

Serum checks 233 modeled interaction pairings for grapefruit (whole fruit) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.