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Selenium (Selenomethionine)

Mineraloral · inferred

Trace mineral with antioxidant properties, crucial for thyroid function and DNA synthesis.

Projected serum levels — 200 mcg (≈ 0.20 mg), once daily

Selenium (Selenomethionine)
Selenium (Selenomethionine) modeled serum levels, 200 mcg (≈ 0.20 mg) once daily over 121 days Population-based pharmacokinetic estimate. Steady state reached after approximately 78 days. 0 2.5 5 7.5 10 Day 0 Day 30 Day 61 Day 91 Day 121 Time on a regular schedule ≈ steady state · day 78
Selenium (Selenomethionine) modeled serum levels with a loading dose of 600 mcg, then 200 mcg (≈ 0.20 mg) once daily The first dose is larger so levels approach steady state faster. 0 2.5 5 7.5 10 Day 0 Day 30 Day 61 Day 91 Day 121 Time on a regular schedule

Maintenance schedule: 200 mcg (≈ 0.20 mg) once daily (oral).

Loading schedule: 600 mcg on day 1, then 200 mcg (≈ 0.20 mg) once daily — reaching therapeutic levels sooner.

Modeled steady state after ~78 days: peak ≈ 7.4 mg, trough ≈ 7.2 mg body load. Population-based estimate over 121 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Mineral
Route modeled
Oral
Model confidence
inferred
Half-life
30 days
Common dose
200 mcg (≈ 0.20 mg)
Suggested maximum
400 mcg/day
Reference dose range
100–400 mcg (single dose)
Suggested cadence
once daily

Documented interactions

  • caution
    Alendronate (Fosamax) + Selenium (Selenomethionine) Chelation

    Alendronate (Fosamax) (bisphosphonate) forms insoluble complexes with Selenium (Selenomethionine) in the GI tract, reducing absorption of both.

  • caution
    Armour Thyroid (Desiccated Thyroid Extract) + Selenium (Selenomethionine) Chelation

    Armour Thyroid (Desiccated Thyroid Extract) (thyroid hormone) forms insoluble complexes with Selenium (Selenomethionine) in the GI tract, reducing absorption of both.

  • caution
    Ciprofloxacin (Cipro) + Selenium (Selenomethionine) Chelation

    Ciprofloxacin (Cipro) (fluoroquinolone antibiotic) forms insoluble complexes with Selenium (Selenomethionine) in the GI tract, reducing absorption of both.

  • caution
    Doxycycline + Selenium (Selenomethionine) Chelation

    Doxycycline (tetracycline antibiotic) forms insoluble complexes with Selenium (Selenomethionine) in the GI tract, reducing absorption of both.

  • caution
    Levofloxacin + Selenium (Selenomethionine) Chelation

    Levofloxacin (fluoroquinolone antibiotic) forms insoluble complexes with Selenium (Selenomethionine) in the GI tract, reducing absorption of both.

  • caution
    Levothyroxine (Synthroid) + Selenium (Selenomethionine) Chelation

    Levothyroxine (Synthroid) (thyroid hormone) forms insoluble complexes with Selenium (Selenomethionine) in the GI tract, reducing absorption of both.

Serum checks 11 modeled interaction pairings for selenium (selenomethionine) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin Clark LC et al. · JAMA, 1996 DOI

    Landmark RCT found 200 mcg/day selenium supplementation reduced total cancer incidence by 37% and cancer mortality by 50% over a mean follow-up of 4.5 years.

  2. Selenium and thyroid disease: from pathophysiology to treatment Duntas LH · European Journal of Endocrinology, 2010 DOI

    Review establishing selenium as essential for thyroid hormone metabolism, with supplementation shown to reduce thyroid antibodies in autoimmune thyroiditis.

  3. Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial Duffield-Lillico AJ et al. · BJU International, 2003 DOI

    Analysis of the NPC trial showed selenium supplementation reduced prostate cancer risk by 52% in men with low baseline selenium levels.

  4. Effects of selenomethionine supplementation on selenium status and thyroid hormone concentrations in healthy adults. Combs GF, Midthune DN, Patterson KY, Canfield WK, Hill AD, Levander OA, Taylor PR, Moler JE, Patterson BH · The American journal of clinical nutrition, 2009 DOI

    This citation reports a human clinical study involving Selenium (Selenomethionine). It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

4 published studies referenced in the app, each with a plain-language summary.