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Micronized Progesterone (Oral)

HRTprescriptionoral · inferred

Bioidentical micronized progesterone capsule. Brands: Prometrium. Take at bedtime (sedating effect via allopregnanolone metabolite). Take WITH food to increase bioavailability 2-3x. Standard HRT dose: 100-200 mg/day. Also used for endometrial protection alongside estrogen.

Projected serum levels — 200 mg, once daily

Micronized Progesterone (Oral)
Micronized Progesterone (Oral) modeled serum levels, 200 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 5 10 15 20 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 200 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 15.1 mg, trough ≈ 2.5 mg body load. Population-based estimate over 15 days for a 200 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
HRT
Route modeled
Oral
Model confidence
inferred
Half-life
8 h
Common dose
200 mg
Suggested maximum
400 mg/day
Reference dose range
100–400 mg (single dose)
Suggested cadence
once daily
Validated against
200 mg oral — Cmax 0.020 mg/L at 2.3 h

Documented interactions

  • contraindicated
    Efavirenz (Sustiva) + Micronized Progesterone (Oral) CYP induction

    Efavirenz (Sustiva) inducer of CYP3A4 predicted to change Micronized Progesterone (Oral) AUC by ~0.18x

  • contraindicated
    Rifampin + Micronized Progesterone (Oral) CYP induction

    Rifampin inducer of CYP3A4 predicted to change Micronized Progesterone (Oral) AUC by ~0.18x

  • danger
    Carbamazepine (Tegretol) + Micronized Progesterone (Oral) CYP induction

    Carbamazepine (Tegretol) inducer of CYP3A4 predicted to change Micronized Progesterone (Oral) AUC by ~0.28x

  • danger
    Clarithromycin (Biaxin) + Micronized Progesterone (Oral) CYP inhibition

    Clarithromycin (Biaxin) mechanism_based of CYP3A4 predicted to change Micronized Progesterone (Oral) AUC by ~2.32x

  • danger
    Combined OC (Drospirenone / Ethinyl Estradiol) + Micronized Progesterone (Oral) Stacked effects

    Combined OC (Drospirenone / Ethinyl Estradiol) and Micronized Progesterone (Oral) both push the androgen receptor, mineralocorticoid receptor, and progesterone receptor in the same direction.

  • danger
    Dasatinib (Sprycel) + Micronized Progesterone (Oral) CYP inhibition

    Dasatinib (Sprycel) time_dependent_inhibitor of CYP3A4 predicted to change Micronized Progesterone (Oral) AUC by ~2.02x

Serum checks 227 modeled interaction pairings for micronized progesterone (oral) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Micronized Progesterone: A New Therapeutic Option de Lignières B · Drug Design and Discovery, 1999 DOI

    Established micronized progesterone as bioidentical alternative to synthetic progestins with better safety profile and reduced breast cancer risk.

  2. Progesterone and the Risk of Breast Cancer: A Systematic Review Fournier A et al. · Breast Cancer Research and Treatment, 2008 DOI

    Meta-analysis showing micronized progesterone associated with significantly lower breast cancer risk compared to synthetic progestins in HRT regimens.

  3. Oral Micronized Progesterone: Pharmacokinetics and Pharmacodynamics Simon JA et al. · Journal of Clinical Endocrinology & Metabolism, 1993 DOI

    PK study showing food increases oral progesterone bioavailability 2-3x, with peak at 2-4 hours and sedating allopregnanolone metabolite peaking at bedtime.

3 published studies referenced in the app, each with a plain-language summary.