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Norelgestromin

Progestin metaboliteprescriptiontransdermal patch · inferred

Active progestin metabolite of norgestimate (and the primary species delivered by the Ortho Evra contraceptive patch). Progesterone receptor agonist with near-zero androgenic activity.

Projected serum levels — 0.15 mg, custom (shown daily)

Norelgestromin
Norelgestromin modeled serum levels, 0.15 mg custom (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 6 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 6
Norelgestromin modeled serum levels with a loading dose of 0.45 mg, then 0.15 mg custom (shown daily) The first dose is larger so levels approach steady state faster. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule

Maintenance schedule: 0.15 mg custom (shown daily) (transdermal patch).

Loading schedule: 0.45 mg on day 1, then 0.15 mg custom (shown daily) — reaching therapeutic levels sooner.

Modeled steady state after ~6 days: peak ≈ 0.23 mg, trough ≈ 0.21 mg body load. Population-based estimate over 15 days for a 0.15 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Progestin metabolite
Route modeled
Transdermal patch
Model confidence
inferred
Half-life
28 h
Common dose
0.15 mg
Suggested maximum
0.30 mg/day
Reference dose range
0.15–0.30 mg (single dose)
Suggested cadence
custom (shown daily)
Validated against
0.15 mg td — Cmax 0.001 mg/L at 48 h

Documented interactions

  • watch
    Combined OC (Drospirenone / Ethinyl Estradiol) + Norelgestromin Stacked effects

    Combined OC (Drospirenone / Ethinyl Estradiol) and Norelgestromin both push the progesterone receptor in the same direction.

  • watch
    Combined OC (Levonorgestrel / Ethinyl Estradiol) + Norelgestromin Stacked effects

    Combined OC (Levonorgestrel / Ethinyl Estradiol) and Norelgestromin both push the progesterone receptor in the same direction.

  • watch
    Combined OC (Norgestimate / Ethinyl Estradiol) + Norelgestromin Stacked effects

    Combined OC (Norgestimate / Ethinyl Estradiol) and Norelgestromin both push the progesterone receptor in the same direction.

  • watch
    Depo-Provera (DMPA Injection) + Norelgestromin Stacked effects

    Depo-Provera (DMPA Injection) and Norelgestromin both push the progesterone receptor in the same direction.

  • watch
    Drospirenone + Norelgestromin Stacked effects

    Drospirenone and Norelgestromin both push the progesterone receptor in the same direction.

  • watch
    Levonorgestrel + Norelgestromin Stacked effects

    Levonorgestrel and Norelgestromin both push the progesterone receptor in the same direction.

Serum checks 19 modeled interaction pairings for norelgestromin across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.