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Nitrous Oxide

Dissociativeoral · inferred

Gaseous dissociative anesthetic and NMDA receptor antagonist with additional opioid receptor modulation. Not metabolized, eliminated unchanged through the lungs within minutes. Exhaled concentration drops from 70% to <10% within 5 minutes. Recreational use ("whippets") produces brief euphoria and dissociation lasting 1-3 minutes. CRITICAL: chronic use irreversibly oxidizes cobalt in vitamin B12, inactivating methionine synthase and causing subacute combined degeneration of the spinal cord (myeloneuropathy).

Projected serum levels — 1 chargers (≈ 8k mg), as needed (shown daily)

Nitrous Oxide
Nitrous Oxide modeled serum levels, 1 chargers (≈ 8k mg) as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 2.5k 5k 7.5k 10k Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 1 chargers (≈ 8k mg) as needed (shown daily) (oral).

Modeled steady state after ~1 days: peak ≈ 7.6k mg, trough ≈ 328 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Dissociative
Route modeled
Oral
Model confidence
inferred
Half-life
5.1 h
Common dose
1 chargers (≈ 8k mg)
Reference dose range
0.50–2 chargers (single dose)
Suggested cadence
as needed (shown daily)

Documented interactions

  • moderate
    Ibogaine + Nitrous Oxide Stacked effects

    Ibogaine and Nitrous Oxide both push the kappa opioid and nmda in the same direction.

  • moderate
    L-Theanine + Nitrous Oxide Stacked effects

    L-Theanine and Nitrous Oxide both push the gaba a and nmda in the same direction.

  • watch
    3-MeO-PCP (3-Methoxyphencyclidine) + Nitrous Oxide Stacked effects

    3-MeO-PCP (3-Methoxyphencyclidine) and Nitrous Oxide both push the nmda in the same direction.

  • watch
    7-Hydroxymitragynine (7-OH) + Nitrous Oxide Stacked effects

    7-Hydroxymitragynine (7-OH) and Nitrous Oxide both push the kappa opioid in the same direction.

  • watch
    Codeine + Nitrous Oxide Stacked effects

    Codeine and Nitrous Oxide both push the kappa opioid in the same direction.

  • watch
    Dextromethorphan (DXM) + Nitrous Oxide Stacked effects

    Dextromethorphan (DXM) and Nitrous Oxide both push the nmda in the same direction.

Serum checks 27 modeled interaction pairings for nitrous oxide across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin Jevtovic-Todorovic V et al. · Nature Medicine, 1998 DOI

    Landmark study establishing nitrous oxide as a non-competitive NMDA receptor antagonist with EC50 of 30-40% for blocking NMDAR-activated currents in hippocampal neurons.

  2. Nitrous Oxide Abuse: Clinical Outcomes, Pharmacology, Pharmacokinetics, Toxicity and Impact on Metabolism Kotsoni A et al. · Toxics, 2023 DOI

    Comprehensive review of nitrous oxide abuse covering rapid pulmonary elimination, B12 inactivation mechanism, myeloneuropathy pathophysiology, and clinical management of chronic abuse.

  3. Nitrous oxide-induced myeloneuropathy Zheng D et al. · International Journal of Neuroscience, 2022 DOI

    Clinical review of nitrous oxide myeloneuropathy documenting irreversible B12 oxidation, subacute combined degeneration, and recovery timelines with B12 supplementation and abstinence.

3 published studies referenced in the app, each with a plain-language summary.