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Modafinil (Provigil)

Eugeroicprescriptionoral · inferred

Wakefulness-promoting agent with a distinct mechanism from traditional stimulants. Reaches steady state in 2-4 days. R-enantiomer (armodafinil) has a longer half-life (10-17h) than S-enantiomer (3-5h).

Projected serum levels — 200 mg, once daily

Modafinil (Provigil)
Modafinil (Provigil) modeled serum levels, 200 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 2 days. 0 125 250 375 500 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 2
Modafinil (Provigil) modeled serum levels with a loading dose of 299 mg, then 200 mg once daily The first dose is larger so levels approach steady state faster. 0 125 250 375 500 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule

Maintenance schedule: 200 mg once daily (oral).

Loading schedule: 299 mg on day 1, then 200 mg once daily — reaching therapeutic levels sooner.

Modeled steady state after ~2 days: peak ≈ 262 mg, trough ≈ 101 mg body load. Population-based estimate over 15 days for a 200 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Eugeroic
Route modeled
Oral
Model confidence
inferred
Half-life
15 h
Common dose
200 mg
Suggested maximum
400 mg/day
Reference dose range
50–400 mg (single dose)
Suggested cadence
once daily
Validated against
200 mg oral — Cmax 4.5 mg/L at 3 h

Documented interactions

  • danger
    Alfuzosin (Uroxatral) + Modafinil (Provigil) CYP induction

    Modafinil (Provigil) inducer of CYP3A4 predicted to change Alfuzosin (Uroxatral) AUC by ~0.50x

  • danger
    Alprazolam (Xanax) + Modafinil (Provigil) CYP induction

    Modafinil (Provigil) inducer of CYP3A4 predicted to change Alprazolam (Xanax) AUC by ~0.50x

  • danger
    Amlodipine (Norvasc) + Modafinil (Provigil) CYP induction

    Modafinil (Provigil) inducer of CYP3A4 predicted to change Amlodipine (Norvasc) AUC by ~0.50x

  • danger
    Astaxanthin + Modafinil (Provigil) CYP induction

    Modafinil (Provigil) inducer of CYP3A4 predicted to change Astaxanthin AUC by ~0.50x

  • danger
    Atogepant (Qulipta) + Modafinil (Provigil) CYP induction

    Modafinil (Provigil) inducer of CYP3A4 predicted to change Atogepant (Qulipta) AUC by ~0.50x

  • danger
    Azithromycin (Z-Pack / Zithromax) + Modafinil (Provigil) CYP induction

    Modafinil (Provigil) inducer of CYP3A4 predicted to change Azithromycin (Z-Pack / Zithromax) AUC by ~0.50x

Serum checks 304 modeled interaction pairings for modafinil (provigil) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Modafinil for excessive sleepiness associated with shift-work sleep disorder Czeisler CA et al. · New England Journal of Medicine, 2005 DOI

    RCT of 209 patients found modafinil 200 mg significantly reduced excessive sleepiness, improved sustained attention, and reduced driving accidents in shift workers.

  2. Effects of modafinil on cognitive and meta-cognitive performance Battleday RM et al. · European Neuropsychopharmacology, 2015 DOI

    Systematic review of 24 studies found modafinil consistently enhanced executive function, attention, and learning in non-sleep-deprived healthy individuals, with minimal side effects.

  3. Modafinil Treatment of Cocaine Dependence: A Systematic Review and Meta-Analysis Sangroula D et al. · Substance Use & Misuse, 2017 DOI

    Meta-analysis of 11 placebo-controlled trials (896 participants) found no overall improvement in cocaine-treatment retention or abstinence. A US-study subgroup showed an abstinence signal, while discontinuations and…

  4. Cognitive enhancement effects of stimulants: a randomized controlled trial testing methylphenidate, modafinil, and caffeine. Repantis D, Bovy L, Ohla K, Kühn S, Dresler M · Psychopharmacology, 2021 DOI

    This citation reports a human clinical study involving a formulation related to Modafinil (Provigil), not the isolated identity. The randomized study compared modafinil with other stimulants; effects remain attributable…

4 published studies referenced in the app, each with a plain-language summary.