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LSA (Ergine / Lysergic Acid Amide)

Psychedelicoral · inferred

Naturally occurring ergoline psychedelic found in morning glory (Ipomoea) and Hawaiian baby woodrose (Argyreia nervosa) seeds. Structurally related to LSD but ~10-20x less potent. Effects last 4-8 hours. Notable vasoconstrictive and nauseating side effects from co-occurring seed alkaloids. Active dose: 2-5 mg pure LSA, or 150-300 morning glory seeds / 4-8 HBWR seeds.

Projected serum levels — 8 seeds (≈ 4 mg), as needed (shown daily)

LSA (Ergine / Lysergic Acid Amide)
LSA (Ergine / Lysergic Acid Amide) modeled serum levels, 8 seeds (≈ 4 mg) as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.50 1 1.5 2 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 8 seeds (≈ 4 mg) as needed (shown daily) (oral).

Modeled steady state after ~1 days: peak ≈ 1.2 mg, trough ≈ 0.003 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Psychedelic
Route modeled
Oral
Model confidence
inferred
Half-life
2.4 h
Common dose
8 seeds (≈ 4 mg)
Reference dose range
4–16 seeds (single dose)
Suggested cadence
as needed (shown daily)

Documented interactions

  • contraindicated
    Carbamazepine (Tegretol) + LSA (Ergine / Lysergic Acid Amide) CYP induction

    Carbamazepine (Tegretol) inducer of CYP3A4 predicted to change LSA (Ergine / Lysergic Acid Amide) AUC by ~0.20x

  • contraindicated
    Clarithromycin (Biaxin) + LSA (Ergine / Lysergic Acid Amide) CYP inhibition

    Clarithromycin (Biaxin) mechanism_based of CYP3A4 predicted to change LSA (Ergine / Lysergic Acid Amide) AUC by ~10.00x

  • contraindicated
    Dasatinib (Sprycel) + LSA (Ergine / Lysergic Acid Amide) CYP inhibition

    Dasatinib (Sprycel) time_dependent_inhibitor of CYP3A4 predicted to change LSA (Ergine / Lysergic Acid Amide) AUC by ~5.00x

  • contraindicated
    Diltiazem + LSA (Ergine / Lysergic Acid Amide) CYP inhibition

    Diltiazem mechanism_based of CYP3A4 predicted to change LSA (Ergine / Lysergic Acid Amide) AUC by ~10.00x

  • contraindicated
    Efavirenz (Sustiva) + LSA (Ergine / Lysergic Acid Amide) CYP induction

    Efavirenz (Sustiva) inducer of CYP3A4 predicted to change LSA (Ergine / Lysergic Acid Amide) AUC by ~0.12x

  • contraindicated
    Grapefruit (whole fruit) + LSA (Ergine / Lysergic Acid Amide) CYP inhibition

    Grapefruit (whole fruit) mechanism_based of CYP3A4 predicted to change LSA (Ergine / Lysergic Acid Amide) AUC by ~10.00x

Serum checks 171 modeled interaction pairings for lsa (ergine / lysergic acid amide) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Lysergic Acid Amide (LSA), an LSD Analog: Systematic Review of Pharmacological Effects, Adverse Outcomes, and Therapeutic Potentials Morales-Garcia JA et al. · Pharmaceuticals, 2024 DOI

    Systematic review of 17 human studies finding LSA causes psychedelic effects at 2-5 mg with significant vegetative side effects (nausea, vasoconstriction). Duration 4-8 hours.

  2. Analysis of Lysergic Acid Amide in Human Serum and Urine After Ingestion of Argyreia Nervosa Seeds Klinke HB et al. · Journal of Analytical Toxicology, 2012 DOI

    First human PK study of LSA after HBWR seed ingestion. Serum levels 0.66-3.15 ng/mL at 2h. Detectable in urine up to 24h, undetectable by 48h.

  3. Argyreia Nervosa: Receptor Profiling of Lysergic Acid Amide and Other Potential Psychedelic LSD-Like Compounds Paulke A et al. · Journal of Ethnopharmacology, 2013 DOI

    Receptor binding study showing LSA has affinity for 5-HT2A, D1, and D2 receptors but ~10-20x lower potency than LSD at the 5-HT2A site.

3 published studies referenced in the app, each with a plain-language summary.