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Fluticasone (Flonase / Flovent)

Corticosteroidprescriptionoral · inferred

Potent synthetic corticosteroid available as nasal spray (Flonase, 50 mcg/spray for allergic rhinitis) and inhaler (Flovent, 44-220 mcg for asthma). High topical potency with low systemic bioavailability (<1% nasal, <1% inhaled after first-pass), minimal HPA axis suppression at standard doses. Onset in 12-24 hours, peak effect in 1-2 weeks for nasal symptoms. Also available as combined fluticasone/salmeterol (Advair) and fluticasone/vilanterol (Breo).

Projected serum levels — 100 mcg (≈ 0.10 mg), twice daily

Fluticasone (Flonase / Flovent)
Fluticasone (Flonase / Flovent) modeled serum levels, 100 mcg (≈ 0.10 mg) twice daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 7 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 7 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 7

Maintenance schedule: 100 mcg (≈ 0.10 mg) twice daily (oral).

Modeled steady state after ~7 days: peak ≈ 0 mg, trough ≈ 0 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Corticosteroid
Route modeled
Oral
Model confidence
inferred
Common dose
100 mcg (≈ 0.10 mg)
Suggested maximum
400 mcg/day
Reference dose range
50–400 mcg (single dose)
Suggested cadence
twice daily

Documented interactions

  • contraindicated
    Carbamazepine (Tegretol) + Fluticasone (Flonase / Flovent) CYP induction

    Carbamazepine (Tegretol) inducer of CYP3A4 predicted to change Fluticasone (Flonase / Flovent) AUC by ~0.20x

  • contraindicated
    Clarithromycin (Biaxin) + Fluticasone (Flonase / Flovent) CYP inhibition

    Clarithromycin (Biaxin) mechanism_based of CYP3A4 predicted to change Fluticasone (Flonase / Flovent) AUC by ~10.00x

  • contraindicated
    Dasatinib (Sprycel) + Fluticasone (Flonase / Flovent) CYP inhibition

    Dasatinib (Sprycel) time_dependent_inhibitor of CYP3A4 predicted to change Fluticasone (Flonase / Flovent) AUC by ~5.00x

  • contraindicated
    Diltiazem + Fluticasone (Flonase / Flovent) CYP inhibition

    Diltiazem mechanism_based of CYP3A4 predicted to change Fluticasone (Flonase / Flovent) AUC by ~10.00x

  • contraindicated
    Efavirenz (Sustiva) + Fluticasone (Flonase / Flovent) CYP induction

    Efavirenz (Sustiva) inducer of CYP3A4 predicted to change Fluticasone (Flonase / Flovent) AUC by ~0.12x

  • contraindicated
    Grapefruit (whole fruit) + Fluticasone (Flonase / Flovent) CYP inhibition

    Grapefruit (whole fruit) mechanism_based of CYP3A4 predicted to change Fluticasone (Flonase / Flovent) AUC by ~10.00x

Serum checks 73 modeled interaction pairings for fluticasone (flonase / flovent) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Fluticasone propionate aqueous nasal spray versus placebo for seasonal allergic rhinitis: a meta-analysis Stempel DA et al. · Annals of Allergy, Asthma & Immunology, 2002 DOI

    Meta-analysis of 6 RCTs confirming fluticasone nasal spray 200 mcg/day significantly improves total nasal symptom scores versus placebo, with onset within 12 hours and peak effect at 3-4 days.

  2. Fluticasone propionate versus salmeterol/fluticasone propionate versus placebo for severe persistent asthma (GOAL study) Bateman ED et al. · American Journal of Respiratory and Critical Care Medicine, 2004 DOI

    Landmark RCT (3421 patients) demonstrating inhaled fluticasone achieves asthma control in majority of patients across severity levels, with combination therapy achieving well-controlled status in 71% versus 41% on…

2 published studies referenced in the app, each with a plain-language summary.