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Delta-8 THC

Cannabinoidoral · inferred

Isomer of delta-9 THC with the double bond at C8 instead of C9. Roughly 50-75% as psychoactive as delta-9 THC. Federally legal in many US states under the 2018 Farm Bill loophole (hemp-derived). Often synthesized from CBD via acid-catalyzed isomerization, purity concerns with unregulated products including contaminants such as delta-10-THC, 9-OH-HHC, heavy metals, and residual acids from conversion process. Metabolized by CYP2C9 and CYP3A4 to 11-hydroxy-delta-8-THC, then to 11-nor-delta-8-THC-9-carboxylic acid.

Projected serum levels — 10 mg, as needed (shown daily)

Delta-8 THC
Delta-8 THC modeled serum levels, 10 mg as needed (shown daily) over 22 days Population-based pharmacokinetic estimate. Steady state reached after approximately 8 days. 0 1.3 2.5 3.8 5 Day 0 Day 6 Day 11 Day 17 Day 22 Time on a regular schedule ≈ steady state · day 8
Delta-8 THC modeled serum levels with a loading dose of 30 mg, then 10 mg as needed (shown daily) The first dose is larger so levels approach steady state faster. 0 1.3 2.5 3.8 5 Day 0 Day 6 Day 11 Day 17 Day 22 Time on a regular schedule

Maintenance schedule: 10 mg as needed (shown daily) (oral).

Loading schedule: 30 mg on day 1, then 10 mg as needed (shown daily) — reaching therapeutic levels sooner.

Modeled steady state after ~8 days: peak ≈ 4.2 mg, trough ≈ 3.5 mg body load. Population-based estimate over 22 days for a 10 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Cannabinoid
Route modeled
Oral
Model confidence
inferred
Half-life
2.8 days
Common dose
10 mg
Reference dose range
5–20 mg (single dose)
Suggested cadence
as needed (shown daily)

Documented interactions

  • danger
    Carbamazepine (Tegretol) + Delta-8 THC CYP induction

    Carbamazepine (Tegretol) inducer of CYP3A4 predicted to change Delta-8 THC AUC by ~0.40x

  • danger
    Efavirenz (Sustiva) + Delta-8 THC CYP induction

    Efavirenz (Sustiva) inducer of CYP3A4 predicted to change Delta-8 THC AUC by ~0.28x

  • danger
    Levothyroxine (Synthroid) + Delta-8 THC Protein binding

    Delta-8 THC may displace Levothyroxine (Synthroid) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free concentration changes…

  • danger
    Rifampin + Delta-8 THC CYP induction

    Rifampin inducer of CYP3A4 predicted to change Delta-8 THC AUC by ~0.28x

  • danger
    St. John's Wort (Hypericum perforatum) + Delta-8 THC CYP induction

    St. John's Wort (Hypericum perforatum) inducer of CYP3A4 predicted to change Delta-8 THC AUC by ~0.48x

  • danger
    Tacrolimus (Prograf) + Delta-8 THC Protein binding

    Delta-8 THC may displace Tacrolimus (Prograf) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free concentration changes can…

Serum checks 234 modeled interaction pairings for delta-8 thc across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Review of delta-8-tetrahydrocannabinol: Comparative pharmacology with delta-9-THC Tagen M, Klumpers LE · British Journal of Pharmacology, 2022 DOI

    Comprehensive comparative review of delta-8-THC and delta-9-THC pharmacology, pharmacokinetics, and clinical effects. Established delta-8-THC as roughly 50-75% as potent as delta-9-THC with similar but slightly…

  2. Novel delta-8-tetrahydrocannabinol vaporizers contain unlabeled adulterants, unintended byproducts of chemical synthesis, and heavy metals Meehan-Atrash J, Rahman I · Chemical Research in Toxicology, 2022 DOI

    Analysis of commercial delta-8-THC vaporizer products found unlabeled adulterants, unintended byproducts from CBD-to-delta-8 acid isomerization synthesis, and heavy metals. Highlights serious consumer safety concerns in…

  3. Delta-8 Tetrahydrocannabinol Product Impurities Ray CL et al. · Molecules, 2022 DOI

    Investigated delta-8-THC product impurities using NMR, HPLC-UV, and HPLC-MS. Identified contaminants from CBD feedstock impurities, poor post-reaction purification, and inadequate analytical certification. Documented…

3 published studies referenced in the app, each with a plain-language summary.