L-Citrulline
Non-essential amino acid that raises plasma arginine levels more effectively than arginine itself. Enhances nitric oxide production and blood flow.
Projected serum levels — 6 g (≈ 6k mg), once daily
Maintenance schedule: 6 g (≈ 6k mg) once daily (oral).
Modeled steady state after ~1 days: peak ≈ 3.3k mg, trough ≈ 0.10 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Amino Acid
- Route modeled
- Oral
- Model confidence
- inferred
- Half-life
- 1.5 h
- Common dose
- 6 g (≈ 6k mg)
- Suggested maximum
- 12 g/day
- Reference dose range
- 3–12 g (single dose)
- Suggested cadence
- once daily
- Validated against
- 3k mg oral — Cmax 120 mg/L at 1 h
Research behind this entry
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L-citrulline supplementation: impact on cardiometabolic health
Comprehensive review showing L-citrulline supplementation effectively increases plasma arginine and nitric oxide, improving blood pressure, blood flow, and exercise performance.
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Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness
Study found 8g citrulline malate before exercise increased the number of repetitions performed during bench press and reduced muscle soreness by 40% at 24-48 hours post-exercise.
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Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction
Study found 1.5g/day L-citrulline for one month improved erection hardness in 50% of men with mild erectile dysfunction, likely through enhanced nitric oxide production.
3 published studies referenced in the app, each with a plain-language summary.