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Calcitriol (1,25-dihydroxyvitamin D3)

Vitamin D metaboliteprescriptionoral · inferred

Hormonally active form of vitamin D3. Formed sequentially via hepatic CYP2R1 (25-hydroxylation → calcifediol) then renal CYP27B1 (1α-hydroxylation). Direct VDR agonist; drives calcium absorption and bone remodeling.

Projected serum levels — 0.25 mcg (≈ 0.000 mg), once daily

Calcitriol (1,25-dihydroxyvitamin D3)
Calcitriol (1,25-dihydroxyvitamin D3) modeled serum levels, 0.25 mcg (≈ 0.000 mg) once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 0.25 mcg (≈ 0.000 mg) once daily (oral).

Modeled steady state after ~1 days: peak ≈ 0.000 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Vitamin D metabolite
Route modeled
Oral
Model confidence
inferred
Half-life
6 h
Common dose
0.25 mcg (≈ 0.000 mg)
Suggested maximum
2 mcg/day
Reference dose range
0.10–2 mcg (single dose)
Suggested cadence
once daily
Validated against
0.001 mg oral — Cmax 0.000 mg/L at 4 h

Documented interactions

  • danger
    Levothyroxine (Synthroid) + Calcitriol (1,25-dihydroxyvitamin D3) Protein binding

    Calcitriol (1,25-dihydroxyvitamin D3) may displace Levothyroxine (Synthroid) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index;…

  • danger
    Tacrolimus (Prograf) + Calcitriol (1,25-dihydroxyvitamin D3) Protein binding

    Calcitriol (1,25-dihydroxyvitamin D3) may displace Tacrolimus (Prograf) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free…

  • danger
    Warfarin (Coumadin) + Calcitriol (1,25-dihydroxyvitamin D3) Protein binding

    Calcitriol (1,25-dihydroxyvitamin D3) may displace Warfarin (Coumadin) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free…

  • warning
    Apigenin + Calcitriol (1,25-dihydroxyvitamin D3) Protein binding

    Apigenin may displace Calcitriol (1,25-dihydroxyvitamin D3) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Aripiprazole (Abilify) + Calcitriol (1,25-dihydroxyvitamin D3) Protein binding

    Aripiprazole (Abilify) may displace Calcitriol (1,25-dihydroxyvitamin D3) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Armour Thyroid (Desiccated Thyroid Extract) + Calcitriol (1,25-dihydroxyvitamin D3) Protein binding

    Calcitriol (1,25-dihydroxyvitamin D3) may displace Armour Thyroid (Desiccated Thyroid Extract) from plasma protein binding sites, transiently raising free drug concentration.

Serum checks 139 modeled interaction pairings for calcitriol (1,25-dihydroxyvitamin d3) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.