Home › Compound Library › Bromazolam

Bromazolam

Benzodiazepineoral · inferred

Designer triazolobenzodiazepine (8-bromo analog of alprazolam) sold in the illicit supply, typically as pressed "pills" or powder, often adulterating street opioids. Similar binding profile to alprazolam with comparable anxiolytic, hypnotic, and amnestic effects. Plasma half-life estimated ~17-18 h in limited published cases. No medical indication; scheduled or controlled in most jurisdictions. Overdose risk is amplified by co-use with opioids and ethanol.

Projected serum levels — 1 mg, as needed (shown daily)

Bromazolam
Bromazolam modeled serum levels, 1 mg as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 4 days. 0 0.63 1.3 1.9 2.5 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 4
Bromazolam modeled serum levels with a loading dose of 2.7 mg, then 1 mg as needed (shown daily) The first dose is larger so levels approach steady state faster. 0 0.63 1.3 1.9 2.5 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule

Maintenance schedule: 1 mg as needed (shown daily) (oral).

Loading schedule: 2.7 mg on day 1, then 1 mg as needed (shown daily) — reaching therapeutic levels sooner.

Modeled steady state after ~4 days: peak ≈ 2.1 mg, trough ≈ 1.4 mg body load. Population-based estimate over 15 days for a 1 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Benzodiazepine
Route modeled
Oral
Model confidence
inferred
Half-life
36 h
Common dose
1 mg
Reference dose range
0.50–2 mg (single dose)
Suggested cadence
as needed (shown daily)

Documented interactions

  • watch
    GABA (Gamma-Aminobutyric Acid) + Bromazolam Stacked effects

    Bromazolam and GABA (Gamma-Aminobutyric Acid) both push the gaba a in the same direction.

  • watch
    Ivermectin (Stromectol) + Bromazolam Stacked effects

    Bromazolam and Ivermectin (Stromectol) both push the gaba a in the same direction.

  • watch
    L-Theanine + Bromazolam Stacked effects

    Bromazolam and L-Theanine both push the gaba a in the same direction.

  • watch
    Taurine + Bromazolam Stacked effects

    Bromazolam and Taurine both push the gaba a in the same direction.

Serum checks 4 modeled interaction pairings for bromazolam across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Bromazolam blood concentrations in postmortem cases — a British Columbia, Canada experience Papsun DM et al. · Journal of Analytical Toxicology, 2023 DOI

    Forensic case series documenting bromazolam in postmortem blood (median ~70 ng/mL); most cases involved polydrug intoxication with fentanyl and other opioids, underscoring the drug's role in the opioid-adulteration…

  2. Characterization of the designer benzodiazepine bromazolam Moosmann B et al. · Drug Testing and Analysis, 2021 DOI

    In vitro receptor binding and metabolic characterization of bromazolam showing high-affinity GABA-A benzodiazepine-site binding and CYP3A4-mediated hydroxylation consistent with alprazolam class behavior.

2 published studies referenced in the app, each with a plain-language summary.