Zeaxanthin
Zeaxanthin is a xanthophyll carotenoid concentrated in macular pigment. It is often studied with lutein and multi-ingredient eye formulations, so combination outcomes cannot be assigned to zeaxanthin alone.
Pharmacokinetic model
A route-level PK model for zeaxanthin is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Carotenoid
- Suggested cadence
- once daily
Research behind this entry
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Lutein plus zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the AREDS2 randomized clinical trial
AREDS2 randomized 4,203 at-risk adults. Adding lutein plus zeaxanthin did not significantly reduce progression to advanced AMD in the primary analysis, though it offered a beta-carotene-free formulation option. The…
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Comparison of plasma responses after non-esterified zeaxanthin and zeaxanthin dipalmitate in human subjects
Twelve volunteers received equal 5 mg doses in a randomized crossover study. Plasma response peaked between 9 and 24 hours and differed by ester form, directly showing why one formulation-independent curve is unsuitable.
2 published studies referenced in the app, each with a plain-language summary.