Yohimbine
Indole alkaloid and alpha-2 adrenergic receptor antagonist. Purified yohimbine is not interchangeable with yohimbe bark: analyses of retail supplements have found large and sometimes unlabeled variation in yohimbine content. Parent-drug exposure varies markedly with CYP2D6 genotype and inhibitors, so a single curve is only a population estimate. Sympathetic effects can include anxiety, tremor, increased blood pressure, and tachycardia; regulatory status varies by country.
Projected serum levels — 5.4 mg, once daily
Maintenance schedule: 5.4 mg once daily (oral).
Modeled steady state after ~1 days: peak ≈ 0.64 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a 5.4 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Stimulant
- Route modeled
- Oral
- Model confidence
- inferred
- Half-life
- 36 min
- Common dose
- 5.4 mg
- Suggested maximum
- 21.6 mg/day
- Reference dose range
- 5.4–21.6 mg (single dose)
- Suggested cadence
- once daily
Research behind this entry
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Biopharmaceutics and metabolism of yohimbine in humans
Healthy volunteers received 5 mg intravenously and 8 mg orally. Mean absolute bioavailability was 22.3% but highly variable, renal excretion of unchanged parent was about 0.1%, and active 11-hydroxy-yohimbine had a…
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Oral Yohimbine as a New Probe Drug to Predict CYP2D6 Activity
In 16 genotype-characterized healthy volunteers, clearance after 5 mg varied from 25.3 to 15,864 mL/min. Paroxetine reduced clearance more than fivefold in extensive metabolizers but not poor metabolizers, confirming…
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Yohimbine as a treatment for erectile dysfunction
This systematic review and meta-analysis included eight randomized trials. Pooled results favored yohimbine-containing interventions, but the monotherapy subgroup did not significantly improve the broader sexual…
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Pharmaceutical quantities of yohimbine found in dietary supplements in the USA
Laboratory analysis of 49 retail products found 0 to 12.1 mg yohimbine per recommended serving. Only 11 labels stated a specific amount, most stated amounts were inaccurate, and only two products combined an accurate…
4 published studies referenced in the app, each with a plain-language summary.