Valerian Root
Valeriana officinalis root preparations marketed mainly for sleep and calming. Human results are preparation-specific and inconsistent across trials; even a trial showing EEG connectivity changes found no between-group improvement on its clinical symptom scales.
Pharmacokinetic model
A route-level PK model for valerian root is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Herb
- Suggested cadence
- once daily
Research behind this entry
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Standardized Extract of Valeriana officinalis Improves Overall Sleep Quality in Human Subjects with Sleep Complaints: A Randomized, Double-Blind, Placebo-Controlled, Clinical Study
Eighty adults with sleep complaints were randomized to a defined valerian extract or placebo for eight weeks; 72 were included in efficacy analyses. Subjective and actigraphy outcomes favored the extract, with…
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Valerian extract alters functional brain connectivity: A randomized double-blind placebo-controlled trial
Four-week trial randomized 64 stressed nonclinical volunteers to 100 mg valerian extract three times daily or placebo. Both groups improved on clinical scales without significant between-group differences; selected EEG…
2 published studies referenced in the app, each with a plain-language summary.