Unifiram (DM-232)

Experimental Nootropic

Unifiram is an experimental pyrrolidinone-derived compound studied in rodent learning models. Its enantiomers differ in preclinical potency, and vendor material has no established clinical identity, dose, or safety.

Pharmacokinetic model

A route-level PK model for unifiram (dm-232) is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category
Experimental Nootropic
Suggested cadence
once daily

Research behind this entry

  1. Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent Martini E, Ghelardini C, Bertucci C, Dei S, Gualtieri F, Guandalini L, Manetti D, Scapecchi S, Teodori E, Romanelli MN · Medicinal Chemistry, 2005 DOI

    Unifiram enantiomers were synthesized and tested in mouse behavioral assays and rat-cortex acetylcholine-release experiments. The R enantiomer was more potent in those preclinical tests; no humans, pharmacokinetics,…

1 published study referenced in the app, each with a plain-language summary.