Trigonelline
Alkaloid
Trigonelline is an N-methyl nicotinic-acid alkaloid present in coffee and fenugreek. Food exposures and purified trigonelline are distinct interventions.
Pharmacokinetic model
A route-level PK model for trigonelline is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Alkaloid
- Suggested cadence
- once daily
Research behind this entry
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Trigonelline is not responsible for the acute increase in plasma homocysteine following ingestion of instant coffee
Eight healthy men received 50 mg purified trigonelline, instant coffee with a similar trigonelline amount, or water in a randomized crossover. Trigonelline did not reproduce coffee's homocysteine effect; the study does…
1 published study referenced in the app, each with a plain-language summary.