Tribulus Terrestris

Herb

Botanical supplement marketed for sexual function, testosterone, and exercise claims. Clinical reviews do not support treating Tribulus as a reliable testosterone booster, and any erectile-function signal is based on a small, heterogeneous evidence base.

Pharmacokinetic model

A route-level PK model for tribulus terrestris is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category
Herb
Suggested cadence
once daily

Research behind this entry

  1. Effects of Tribulus (Tribulus terrestris L.) Supplementation on Erectile Dysfunction and Testosterone Levels in Men—A Systematic Review of Clinical Trials Vilar Neto JO, de Moraes WMAM, Pinto DV, da Silva CA, Caminha JSR, Nunes Filho JCC, Reis CEG, Prestes J, Santos HO, De Francesco Daher E · Nutrients, 2025 DOI

    Systematic review found some erectile-function signals but no consistent evidence that Tribulus raises testosterone in men. Included trials varied in extracts, doses, populations, and quality, limiting generalization.

  2. The Effects of 6 Weeks of Tribulus terrestris L. Supplementation on Body Composition, Hormonal Response, Perceived Exertion, and CrossFit Performance: A Randomized, Single-Blind, Placebo-Controlled Study Fernández-Lázaro D, Mielgo-Ayuso J, Del Valle Soto M, Adams DP, González-Bernal JJ, Seco-Calvo J · Nutrients, 2021 DOI

    Six-week randomized single-blind study evaluated one Tribulus preparation in trained CrossFit participants. The small, product-specific study does not establish a general hormone or performance effect across commercial…

2 published studies referenced in the app, each with a plain-language summary.