Tramadol Extended Release (Ultram ER)
Once-daily extended-release tramadol matrix tablet for chronic pain. Swallow whole; crushing or chewing releases the full dose at once and increases seizure and opioid-toxicity risk.
Projected serum levels — 100 mg, once daily
Maintenance schedule: 100 mg once daily (oral).
Loading schedule: 163 mg on day 1, then 100 mg once daily — reaching therapeutic levels sooner.
Modeled steady state after ~2 days: peak ≈ 29.4 mg, trough ≈ 18.4 mg body load. Population-based estimate over 15 days for a 100 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Analgesic
- Route modeled
- Oral
- Model confidence
- predicted
- Half-life
- 8 h
- Common dose
- 100 mg
- Suggested maximum
- 300 mg/day
- Reference dose range
- 100–300 mg (single dose)
- Suggested cadence
- once daily
Research behind this entry
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Tramadol: a review of its use in perioperative pain
Comprehensive review establishing tramadol's efficacy for moderate pain with analgesic potency approximately 1/10th that of morphine, dual mechanism of action, and lower respiratory depression risk.
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Clinical pharmacokinetics of tramadol
Definitive PK review establishing tramadol half-life of 5-7 hours, 70% bioavailability, CYP2D6-dependent formation of active M1 metabolite (half-life 8h, 200x higher opioid affinity), and the clinical impact of CYP2D6…
2 published studies referenced in the app, each with a plain-language summary.