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Thiamine (Vitamin B1)

Vitaminoral · inferred

Water-soluble vitamin essential for carbohydrate metabolism and nerve function. Deficiency causes beriberi and Wernicke encephalopathy.

Projected serum levels — 100 mg, once daily

Thiamine (Vitamin B1)
Thiamine (Vitamin B1) modeled serum levels, 100 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.50 1 1.5 2 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 100 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 1.7 mg, trough ≈ 0.001 mg body load. Population-based estimate over 15 days for a 100 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Vitamin
Route modeled
Oral
Model confidence
inferred
Half-life
1.5 h
Common dose
100 mg
Suggested maximum
500 mg/day
Reference dose range
50–500 mg (single dose)
Suggested cadence
once daily
Validated against
100 mg oral — Cmax 0.010 mg/L at 3 h

Documented interactions

  • warning
    Ethanol (Alcohol) + Thiamine (Vitamin B1) Depletion

    Alcohol impairs thiamine absorption, increases urinary excretion, and depletes hepatic stores. Chronic use causes Wernicke encephalopathy.

Serum checks 1 modeled interaction pairings for thiamine (vitamin b1) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Wernicke encephalopathy Sechi G et al. · Lancet Neurology, 2007 DOI

    Authoritative review of Wernicke encephalopathy from thiamine deficiency, showing it is underdiagnosed and not limited to alcohol use, with recommended parenteral thiamine treatment.

  2. Thiamine supplementation, obesity, and chronic kidney disease in patients with diabetes mellitus Rabbani N et al. · Biology, 2020 DOI

    Review showing high-dose thiamine supplementation may reverse early diabetic nephropathy by reducing advanced glycation end products and oxidative stress.

  3. Effect of vitamin B1 supplementation on bone turnover markers in adults: an exploratory single-arm pilot study. Hara A, Takazawa C, Tsujiguchi H, Zhao J, Nakamura M, Kasahara T, Shimizu Y, Nakamura H · Journal of nutritional science, 2025 DOI

    This citation reports a human clinical study involving Thiamine (Vitamin B1). It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

3 published studies referenced in the app, each with a plain-language summary.