Sulbutiamine
Lipophilic synthetic vitamin B1 derivative marketed for fatigue and cognition. Reviews find limited and heterogeneous clinical evidence, with much of the mechanistic literature preclinical.
Pharmacokinetic model
A route-level PK model for sulbutiamine is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Nootropic
- Suggested cadence
- once daily
Research behind this entry
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Role of the Synthetic B1 Vitamin Sulbutiamine on Health
Narrative review covered chemistry, experimental pharmacology, and small clinical studies. It concluded that evidence remained limited and did not establish broad nootropic effectiveness.
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Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia
Clinical study examined sulbutiamine as an adjunct for infection- associated asthenia. Its condition-specific design does not establish generalized cognitive enhancement or long-term benefit.
2 published studies referenced in the app, each with a plain-language summary.