Sodium Bicarbonate
Buffering Agent
Sodium bicarbonate is an alkalinizing salt used medically and studied as an exercise buffer. Large acute doses can cause substantial gastrointestinal symptoms, sodium loading, and alkalosis; performance findings are protocol- and activity-specific.
Pharmacokinetic model
A route-level PK model for sodium bicarbonate is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Buffering Agent
- Suggested cadence
- once daily
Research behind this entry
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Sodium Bicarbonate Ingestion in a Fasted State Improves 16.1-km Cycling Time-Trial Performance
Ten trained male cyclists completed randomized crossover time trials after 0.3 g/kg in gelatin capsules, enteric capsules, or placebo. Both active forms improved time by roughly 34-40 seconds; enteric capsules caused…
1 published study referenced in the app, each with a plain-language summary.