Sodium Ascorbate

Vitamin C Salt

Sodium ascorbate is the sodium salt of ascorbic acid. It delivers both ascorbate and sodium; oral supplements and high-dose IV solutions have different risks and kinetics, especially in renal disease, sodium-sensitive states, and glucose-6-phosphate dehydrogenase deficiency.

Pharmacokinetic model

A route-level PK model for sodium ascorbate is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category: Vitamin C Salt
Suggested cadence: once daily

Research behind this entry

Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial Yanase F, Spano S, Maeda A, Chaba A, Naorungroj T, Ow CPC, Lankadeva YR, May CN, Betrie AH, Lane DJR, Eastwood GM, Plummer MP, Bellomo R · Critical Care, 2023 DOI
Thirty septic-shock patients received 60 g IV sodium ascorbate or placebo. The primary 24-hour urine-output difference narrowly missed significance; sodium rose more, with one hypernatremia and one hemolysis event. This…

1 published study referenced in the app, each with a plain-language summary.