Silybin (Silibinin)
Milk Thistle Flavonolignan
Silybin is the major paired flavonolignan of milk-thistle extracts. Silybin A, silybin B, silymarin mixtures, and phospholipid complexes require distinct models.
Pharmacokinetic model
A route-level PK model for silybin (silibinin) is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Milk Thistle Flavonolignan
- Suggested cadence
- once daily
Research behind this entry
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Relative Bioavailability of Silybin A and Silybin B From 2 Multiconstituent Dietary Supplement Formulations Containing Milk Thistle Extract: A Single-dose Study
Twelve healthy volunteers received two milk-thistle formulations in crossover fashion. Dose-corrected Cmax differed by roughly 3.7- to 4.5-fold for silybin A and B, confirming strong formulation dependence.
1 published study referenced in the app, each with a plain-language summary.