Serrapeptase
Serratiopeptidase is a bacterial protease sold as an oral enzyme supplement. Small clinical studies exist for short-term postoperative outcomes, but systematic review found the overall evidence low quality and long-term safety inadequately characterized.
Pharmacokinetic model
A route-level PK model for serrapeptase is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Enzyme Supplement
- Suggested cadence
- once daily
Research behind this entry
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Serratiopeptidase: a systematic review of the existing evidence
Review identified small and methodologically weak clinical studies, insufficient evidence for analgesic or supplement use, and inadequate long-term safety data. It does not support cardiovascular plaque-removal claims.
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Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars
Randomized double-blind crossover study in 24 people reported less postoperative swelling and pain but no difference in mouth opening. The small short-term dental study cannot establish broad systemic or chronic…
2 published studies referenced in the app, each with a plain-language summary.