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Semax

Peptideinsufflated · inferred

Synthetic heptapeptide analog of ACTH(4-7) with C-terminal Pro-Gly-Pro modification. Neuroprotective and nootropic peptide developed in Russia. Plasma half-life ~20-30 min but functional neurological effects persist for hours. Administered intranasally. Enhances BDNF expression and modulates serotonergic/dopaminergic systems.

Projected serum levels — 600 mcg (≈ 0.60 mg), once daily

Semax
Semax modeled serum levels, 600 mcg (≈ 0.60 mg) once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 600 mcg (≈ 0.60 mg) once daily (insufflated).

Modeled steady state after ~1 days: peak ≈ 0.17 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Peptide
Route modeled
Insufflated
Model confidence
inferred
Half-life
22 min
Common dose
600 mcg (≈ 0.60 mg)
Suggested maximum
1.8k mcg/day
Reference dose range
300–1.8k mcg (single dose)
Suggested cadence
once daily

Documented interactions

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    Lion's Mane (Hericium erinaceus) + Semax Stacked effects

    Lion's Mane (Hericium erinaceus) and Semax both push the nerve growth factor pathway in the same direction.

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    Melanotan II + Semax Stacked effects

    Melanotan II and Semax both push the mc4r in the same direction.

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    Noopept (GVS-111 / Omberacetam) + Semax Stacked effects

    Noopept (GVS-111 / Omberacetam) and Semax both push the bdnf signaling in the same direction.

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    PQQ (Pyrroloquinoline Quinone) + Semax Stacked effects

    PQQ (Pyrroloquinoline Quinone) and Semax both push the nerve growth factor pathway in the same direction.

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    PT-141 (Bremelanotide) + Semax Stacked effects

    PT-141 (Bremelanotide) and Semax both push the mc4r in the same direction.

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    Selank + Semax Stacked effects

    Selank and Semax both push the bdnf signaling in the same direction.

Serum checks 7 modeled interaction pairings for semax across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Selank and Semax modulate the activity of neurotransmitter systems Eremin KO et al. · Bulletin of Experimental Biology and Medicine, 2004 DOI

    Demonstrated that Semax modulates dopaminergic and serotonergic neurotransmitter systems in rat brain, supporting its nootropic and neuroprotective mechanisms of action.

  2. Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats Filippenkov IB et al. · Genes, 2020 DOI

    Transcriptomic analysis revealing Semax modulates expression of 70+ genes involved in inflammation, apoptosis, and neurotransmission following ischemic brain injury in rats.

  3. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia Medvedeva EV et al. · BMC Genomics, 2014 DOI

    Microarray study showing Semax treatment after focal ischemia suppresses pro-inflammatory gene expression while activating genes involved in neurovascular repair.

  4. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, Dubynina EV, Novosadova EV, Andreeva LA, Alfeeva LY, Kamensky AA, Grivennikov IA, Myasoedov NF, Engele J · Brain research, 2006 DOI

    This citation reports an animal study involving Semax. It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

4 published studies referenced in the app, each with a plain-language summary.