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SAM-e (S-Adenosylmethionine)

Amino Acidoral · inferred

Universal methyl donor involved in over 100 biochemical reactions. Supports mood, liver health, and joint function. Requires enteric coating for oral bioavailability.

Projected serum levels — 400 mg, once daily

SAM-e (S-Adenosylmethionine)
SAM-e (S-Adenosylmethionine) modeled serum levels, 400 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 2.5 5 7.5 10 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 400 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 9.6 mg, trough ≈ 0.18 mg body load. Population-based estimate over 15 days for a 400 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Amino Acid
Route modeled
Oral
Model confidence
inferred
Half-life
3 h
Common dose
400 mg
Suggested maximum
1.6k mg/day
Reference dose range
200–1.6k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • warning
    Escitalopram (Lexapro) + SAM-e (S-Adenosylmethionine) Potentiation

    SAMe increases serotonin activity. Combined with SSRIs, risk of serotonin syndrome.

  • warning
    Fluoxetine (Prozac) + SAM-e (S-Adenosylmethionine) Potentiation

    SAMe increases serotonin activity. Combined with SSRIs, risk of serotonin syndrome.

  • warning
    Sertraline (Zoloft) + SAM-e (S-Adenosylmethionine) Potentiation

    SAMe increases serotonin, dopamine, and norepinephrine. Combined with SSRIs, risk of serotonin syndrome.

Serum checks 3 modeled interaction pairings for sam-e (s-adenosylmethionine) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial Najm WI et al. · BMC Musculoskeletal Disorders, 2004 DOI

    Crossover trial found SAM-e (1200 mg/day) had similar efficacy to celecoxib for osteoarthritis pain by month 2, with fewer side effects.

  2. Oral SAMe compared with oral imipramine in the treatment of depression: a randomized, double-blind, parallel-group trial Delle Chiaie R et al. · American Journal of Clinical Nutrition, 2002 DOI

    RCT found SAM-e (1600 mg/day) was as effective as the tricyclic antidepressant imipramine for treating major depression, with a faster onset and fewer side effects.

2 published studies referenced in the app, each with a plain-language summary.