Saffron
Crocus sativus stigma and standardized extracts studied for mood, sleep, and other outcomes. Several small trials report product-specific signals, but results should not be generalized across preparations or treated as a substitute for established care.
Pharmacokinetic model
A route-level PK model for saffron is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Herb
- Suggested cadence
- once daily
Research behind this entry
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An Examination into the Effects of a Saffron Extract (Affron) on Mood and General Wellbeing in Adults Experiencing Low Mood: A Randomized, Double-Blind, Placebo-Controlled Trial
Randomized trial evaluated one branded standardized saffron extract in adults reporting low mood. Product-specific questionnaire outcomes do not establish an antidepressant indication or generalize to culinary saffron.
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Effects of Saffron Extract on Sleep Quality: A Randomized Double-Blind Controlled Clinical Trial
Controlled trial assessed one saffron extract for sleep outcomes over a limited period. Findings are formulation-specific and require independent replication with objective sleep measures and broader populations.
2 published studies referenced in the app, each with a plain-language summary.