S-Acetyl Glutathione

Glutathione Prodrug

S-acetyl glutathione is a thioester derivative intended to deliver glutathione after deacetylation. It is distinct from reduced, liposomal, sublingual, and intravenous glutathione products.

Pharmacokinetic model

A route-level PK model for s-acetyl glutathione is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category
Glutathione Prodrug
Suggested cadence
once daily

Research behind this entry

  1. Oral Administration of S-acetyl-glutathione: Impact on the Levels of Glutathione in Plasma and in Erythrocytes of Healthy Volunteers Fanelli S, Francioso A, Cavallaro RA, d'Erme M, Putignano P, Miraglia N, Mosca L · International Journal of Clinical Nutrition & Dietetics, 2018 DOI

    Eighteen healthy adults entered a randomized open-label crossover of about 3.5 g oral S-acetyl glutathione versus reduced glutathione. Parent SAG was never quantifiable, glutathione responses were highly variable, and…

1 published study referenced in the app, each with a plain-language summary.