Rosmarinic Acid

Polyphenol

Rosmarinic acid is a plant polyphenol found in lemon balm, rosemary, and other herbs. Extract composition, food, and conjugation materially alter measured exposure.

Pharmacokinetic model

A route-level PK model for rosmarinic acid is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category
Polyphenol
Suggested cadence
once daily

Research behind this entry

  1. Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals Noguchi-Shinohara M, Ono K, Hamaguchi T, Iwasa K, Nagai T, Kobayashi S, Nakamura H, Yamada M · PLoS One, 2015 DOI

    Eleven healthy adults received characterized lemon-balm extract containing 250 or 500 mg rosmarinic acid. Serum total rosmarinic acid peaked near one hour when fasted, while food increased exposure and delayed…

1 published study referenced in the app, each with a plain-language summary.