R-Alpha-Lipoic Acid
R-alpha-lipoic acid is the naturally occurring R enantiomer of lipoic acid. It is distinct from racemic R,S-alpha-lipoic acid. Solubility, polymerization, salt form, food, and formulation materially change oral exposure, so evidence must be matched to the exact product.
Pharmacokinetic model
A route-level PK model for r-alpha-lipoic acid is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Lipoic Acid Enantiomer
- Suggested cadence
- once daily
Research behind this entry
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The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects
Twelve healthy adults received 600 mg R-lipoic acid as a pre-dissolved sodium R-lipoate solution. The formulation produced rapid exposure and differed from free or racemic lipoic acid. These data are specific to the…
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Gastrointestinal Tolerability and Absorption of R- Versus R,S-Lipoic Acid in Progressive Multiple Sclerosis: A Randomized Crossover Trial
Twenty participants entered a double-blind crossover comparison of 600 mg R-LA with 1200 mg racemic R,S-LA. R-enantiomer exposure was bioequivalent between the regimens and gastrointestinal reports were fewer with R-LA,…
2 published studies referenced in the app, each with a plain-language summary.