Pyridoxal 5'-Phosphate (PLP)

Vitamin B6 Coenzyme

Pyridoxal 5'-phosphate is the principal active coenzyme form of vitamin B6. It is distinct from pyridoxine and other B6 vitamers, yet enzymatic dephosphorylation, interconversion, albumin binding, and endogenous pools prevent treating an oral dose as a simple circulating parent.

Pharmacokinetic model

A route-level PK model for pyridoxal 5'-phosphate (plp) is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category: Vitamin B6 Coenzyme
Suggested cadence: once daily

Research behind this entry

Efficacy and safety of pyridoxal 5-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial MEND-CABG II Investigators, Alexander JH, Emery RW Jr, Carrier M, Ellis SJ, Mehta RH, Hasselblad V, Menasche P, Khalil A, Cote R, Bennett-Guerrero E, Mack MJ, Schuler G, Harrington RA, Tardif JC · JAMA, 2008 DOI
In 3,023 CABG patients, pharmaceutical MC-1 at 250 mg/day did not reduce cardiovascular death or nonfatal myocardial infarction. Day-4 mortality was higher than placebo while 30-day mortality was similar; this exact…

1 published study referenced in the app, each with a plain-language summary.