Pterostilbene

Polyphenol

Pterostilbene is a dimethylated stilbene related to resveratrol. Human evidence is limited; a standalone trial found an LDL increase alongside a blood-pressure reduction, while a combination trial did not improve muscle recovery after experimental injury.

Pharmacokinetic model

A route-level PK model for pterostilbene is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category: Polyphenol
Suggested cadence: once daily

Research behind this entry

A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals Jensen JB, Dollerup OL, Møller AB, Billeskov TB, Dalbram E, Chubanava S, Damgaard MV, Dellinger RW, Trošt K, Moritz T, Ringgaard S, Møller N, Treebak JT, Farup J, Jessen N · JCI Insight, 2022 DOI
Thirty-two older adults received nicotinamide riboside plus 200 mg/day pterostilbene or placebo. The combination did not improve muscle stem-cell recruitment or recovery after induced injury, and cannot isolate either…
Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial Riche DM, Riche KD, Blackshear CT, McEwen CL, Sherman JJ, Wofford MR, Griswold ME · Evidence-Based Complementary and Alternative Medicine, 2014 DOI
Eighty adults with elevated cholesterol were randomized for six to eight weeks. Pterostilbene monotherapy increased LDL by 17.1 mg/dL; the high dose lowered blood pressure. The short trial raises a lipid safety concern…

2 published studies referenced in the app, each with a plain-language summary.