Propranolol Extended Release (Inderal LA)
Once-daily sustained-release propranolol capsule. It produces a later peak and flatter concentrations but is not a simple milligram-for-milligram substitute for immediate-release propranolol.
Projected serum levels — 80 mg, once daily
Maintenance schedule: 80 mg once daily (oral).
Modeled steady state after ~1 days: peak ≈ 6.0 mg, trough ≈ 0.48 mg body load. Population-based estimate over 15 days for a 80 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Beta Blocker
- Route modeled
- Oral
- Model confidence
- predicted
- Half-life
- 10 h
- Common dose
- 80 mg
- Suggested maximum
- 320 mg/day
- Reference dose range
- 60–320 mg (single dose)
- Suggested cadence
- once daily
Research behind this entry
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Propranolol in the treatment of essential tremor
Early double-blind crossover trial demonstrating propranolol significantly reduces essential tremor amplitude compared to placebo, establishing beta-blockers as first-line tremor therapy.
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Effect of propranolol in the treatment of performance anxiety in musicians
Double-blind placebo-controlled study showing propranolol improved musical performance quality and reduced stage fright symptoms in professional musicians.
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Pharmacokinetics of propranolol: a review
Comprehensive pharmacokinetic review establishing propranolol half-life of 3-6 hours, 25% oral bioavailability due to extensive hepatic first-pass metabolism, and wide interindividual variability.
3 published studies referenced in the app, each with a plain-language summary.