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Prednisolone

Glucocorticoidprescriptionoral · inferred

Active 11β-hydroxylated metabolite of prednisone (reduction by 11β-HSD1 in liver). Itself a directly-dosed drug (Pediapred, Orapred). Glucocorticoid receptor agonist with ~4× cortisol potency.

Projected serum levels — 20 mg, once daily

Prednisolone
Prednisolone modeled serum levels, 20 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 5 10 15 20 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 20 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 11.9 mg, trough ≈ 0.075 mg body load. Population-based estimate over 15 days for a 20 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Glucocorticoid
Route modeled
Oral
Model confidence
inferred
Half-life
3 h
Common dose
20 mg
Suggested maximum
80 mg/day
Reference dose range
2.5–80 mg (single dose)
Suggested cadence
once daily
Validated against
20 mg oral — Cmax 0.60 mg/L at 1.5 h

Documented interactions

  • moderate
    Betamethasone + Prednisolone Stacked effects

    Betamethasone and Prednisolone both push the glucocorticoid receptor and mineralocorticoid receptor in the same direction.

  • moderate
    Dexamethasone (Decadron) + Prednisolone Stacked effects

    Dexamethasone (Decadron) and Prednisolone both push the glucocorticoid receptor and mineralocorticoid receptor in the same direction.

  • moderate
    Hydrocortisone (Cortef) + Prednisolone Stacked effects

    Hydrocortisone (Cortef) and Prednisolone both push the glucocorticoid receptor and mineralocorticoid receptor in the same direction.

  • moderate
    Methylprednisolone (Medrol) + Prednisolone Stacked effects

    Methylprednisolone (Medrol) and Prednisolone both push the glucocorticoid receptor and mineralocorticoid receptor in the same direction.

  • moderate
    Prednisone + Prednisolone Stacked effects

    Prednisolone and Prednisone both push the glucocorticoid receptor and mineralocorticoid receptor in the same direction.

  • moderate
    Triamcinolone + Prednisolone Stacked effects

    Prednisolone and Triamcinolone both push the glucocorticoid receptor and mineralocorticoid receptor in the same direction.

Serum checks 12 modeled interaction pairings for prednisolone across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.