Piperine
Major pungent alkaloid from black pepper, often added as a bioavailability enhancer. Its inhibition of drug-metabolizing enzymes and transport processes can alter exposure to medicines and supplements.
Pharmacokinetic model
A route-level PK model for piperine is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Supplement
- Suggested cadence
- once daily
Research behind this entry
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Safety Aspects of the Use of Isolated Piperine Ingested as a Bolus
Safety review examined isolated bolus piperine, including potential interactions and uncertainty around supplemental exposure. It does not establish efficacy for using piperine as a bioavailability enhancer.
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Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies
Review evaluated curcumin-piperine combinations rather than piperine monotherapy. Combination findings cannot isolate piperine's clinical effect or define its standalone pharmacokinetics.
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Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.
This citation reports a human clinical study involving a formulation related to Piperine, not the isolated identity. The pharmacokinetic study coadministered piperine with curcumin and does not establish piperine-only…
3 published studies referenced in the app, each with a plain-language summary.