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Phosphatidylserine (PS)

Nootropicoral · inferred

Phospholipid concentrated in brain cell membranes, essential for cell signalling, apoptosis regulation, and neurotransmitter release. Biphasic plasma kinetics with rapid cellular uptake. Supplementation increases phosphatidylserine content in cell membranes. Modern supplements use soy or sunflower-derived PS.

Projected serum levels — 100 mg, once daily

Phosphatidylserine (PS)
Phosphatidylserine (PS) modeled serum levels, 100 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.50 1 1.5 2 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 100 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 1.8 mg, trough ≈ 0.002 mg body load. Population-based estimate over 15 days for a 100 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Nootropic
Route modeled
Oral
Model confidence
inferred
Half-life
14 min
Common dose
100 mg
Suggested maximum
300 mg/day
Reference dose range
50–300 mg (single dose)
Suggested cadence
once daily

Research behind this entry

  1. Effect of phosphatidylserine on cognitive function in the elderly: a systematic review and meta-analysis Ma X et al. · Journal of Korean Medical Science, 2022 DOI

    Systematic review and meta-analysis of 5 RCTs (783 participants) and 4 pre-post studies (178 participants) concluded that phosphatidylserine has a positive effect on memory in older adults with cognitive decline.

  2. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints Kato-Kataoka A et al. · Journal of Clinical Biochemistry and Nutrition, 2010 DOI

    Double-blind RCT in 78 elderly subjects (50-69 years) showed 100-300 mg/day soy-derived PS for 6 months significantly improved memory scores in the subgroup with lowest baseline performance.

  3. Effects of phosphatidylserine on exercising humans Starks MA et al. · Sports Medicine, 2008 DOI

    Review of exercise studies demonstrated 300-800 mg/day phosphatidylserine blunts cortisol response to exercise stress and may improve exercise capacity and recovery.

  4. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T · Journal of clinical biochemistry and nutrition, 2010 DOI

    This citation reports a human primary study involving Phosphatidylserine (PS). It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

4 published studies referenced in the app, each with a plain-language summary.