PEG-MGF

Experimental Peptide

PEG-MGF is a vendor term for PEGylated mechano-growth-factor-related peptides. Sequence, PEG size, attachment site, identity, potency, and pharmacokinetics are not standardized.

Pharmacokinetic model

A route-level PK model for peg-mgf is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category: Experimental Peptide
Suggested cadence: once daily

Research behind this entry

Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells Fornaro M, Hinken AC, Needle S, Hu E, Trendelenburg AU, Mayer A, Rosenstiel A, Chang C, Meier V, Billin AN, Becherer JD, Brace AD, Evans WJ, Glass DJ, Russell AJ · American Journal of Physiology-Endocrinology and Metabolism, 2014 DOI
Native and stabilized MGF-related peptides failed to reproduce claimed myoblast effects across human and mouse cell systems. This is explicit parent-analogue evidence only; it neither tests PEG-MGF nor supplies in-vivo…

1 published study referenced in the app, each with a plain-language summary.