Papain
Proteolytic Enzyme
Papain is a cysteine protease obtained from papaya latex. Purified enzyme, papaya fruit preparations, topical dental gels, and multi-enzyme digestive products are different interventions; papaya or latex allergy can be relevant.
Pharmacokinetic model
A route-level PK model for papain is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Proteolytic Enzyme
- Suggested cadence
- once daily
Research behind this entry
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Anti-plaque and anti-gingivitis effect of Papain, Bromelain, Miswak and Neem containing dentifrice: A randomized controlled trial
Orthodontic patients used a toothpaste combining papain, bromelain, miswak, and neem. Plaque and gingival indices favored the combination, but the topical multi-ingredient result cannot isolate papain or support an oral…
1 published study referenced in the app, each with a plain-language summary.