Nobiletin
Nobiletin is a polymethoxylated flavone found in citrus peel. Most efficacy claims derive from cell and animal models; the limited human evidence uses mixtures and cannot establish isolated-nobiletin benefit.
Pharmacokinetic model
A route-level PK model for nobiletin is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Citrus Flavonoid
- Suggested cadence
- once daily
Research behind this entry
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Nobiletin improves memory impairment and amyloid-beta pathology in a transgenic mouse model of Alzheimer's disease
Four months of nobiletin changed memory and amyloid measures in a transgenic mouse model. This does not establish prevention or treatment of Alzheimer disease in humans.
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Effectiveness and Safety of a Mixture of Nobiletin and Tangeretin in Nocturia Patients: A Randomized, Placebo-Controlled, Double-Blind, Crossover Study
Thirty-six of 40 older participants completed a crossover trial of a nobiletin-tangeretin mixture. The primary bladder-capacity endpoint showed little change; nighttime frequency fell by about 0.5 voids. The mixture…
2 published studies referenced in the app, each with a plain-language summary.