NADH
NADH is the reduced form of nicotinamide adenine dinucleotide, an endogenous redox cofactor. It is not interchangeable with oxidized NAD+ or the precursors nicotinamide riboside and NMN. Direct oral evidence is small and often uses stabilized proprietary formulations or combination products.
Pharmacokinetic model
A route-level PK model for nadh is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Coenzyme Supplement
- Suggested cadence
- once daily
Research behind this entry
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Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial
This randomized trial studied NADH only in combination with coenzyme Q10. Any reported fatigue or quality-of-life difference therefore cannot be attributed to NADH alone, and the study did not validate a serum model.
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Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome
A randomized crossover pilot enrolled 26 people and compared 10 mg/day of a stabilized oral NADH product with placebo for four weeks. More participants met the study's response definition on NADH, but the sample was…
2 published studies referenced in the app, each with a plain-language summary.