MIF-1
Experimental Peptide
MIF-1, also called melanocyte-inhibiting factor-1, is the tripeptide Pro-Leu-Gly-NH2. Most evidence is old and preclinical; it does not support self-treatment of depression or a human dosing recommendation.
Pharmacokinetic model
A route-level PK model for mif-1 is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Experimental Peptide
- Suggested cadence
- once daily
Research behind this entry
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MIF-1 is active in a chronic stress animal model of depression
Rats exposed to unpredictable chronic stress received daily intraperitoneal MIF-1. Low doses changed open-field measures in the same direction as imipramine, while a high dose worsened stress effects and produced…
1 published study referenced in the app, each with a plain-language summary.